Synthetic cannabinoids

What are synthetic cannabinoids?

Synthetic cannabinoids are artificial (man-made) chemical compounds that alter the mind. They are sprayed on the dried and crushed matter of a plant so that they can be smoked, or sold as liquids that are vaporized and inhaled in electronic cigarettes or other devices. These products are also called herbal or liquid incense.

They are called cannabinoids because they are similar to the chemicals found in the marijuana plant. Because of this similarity, synthetic cannabinoids are sometimes mistakenly called “synthetic marijuana” or “fake weed”. They are often marketed as legal and safe alternatives to that drug, but the reality is that synthetic cannabinoids pose risks and can affect the brain far more powerfully than marijuana. Its real effects can be unpredictable and, in some cases, more dangerous. These substances can become life-threatening. Buy cannabis indica online

Synthetic cannabinoids are a part of a gaggle of medication referred to as new hallucinogenic substances (NPS). These are substances that alter the mind but are not regulated. They have recently appeared on the market and their purpose is to cause the same effects as illegal drugs. Some of these substances may have been around for several years, but are now back on the market with different chemical structures or because they have regained popularity.

Manufacturers sell these products in colorful aluminum foil containers and plastic bottles to appeal to consumers. They market them under a wide variety of brands; There are currently hundreds of them, including K2, Spice, Joker, Black Mamba, Kush, and Kronic. Buy Hemp Seed Oil

For several years, it was easy to buy synthetic cannabinoid blends at novelty and drug paraphernalia stores, at gas stations, and online. Since the chemicals used in them do not have any medical benefits but have a high potential for abuse, the authorities have made the sale, purchase, and possession of these substances illegal. However, manufacturers try to circumvent the laws by modifying the chemical formulas of the mixtures.

The ease with which they can be obtained and the belief that synthetic cannabinoids is “natural” and therefore not harmful have probably contributed to consumption among young people. Another reason they are used on an ongoing basis is that traditional drug use tests do not easily detect many of the chemicals used in these products.

How are synthetic cannabinoids consumed?

The most common way to consume synthetic cannabinoids is to smoke the dry matter of the plant. That dry matter sprayed with synthetic cannabinoids is also sometimes mixed with marijuana or drunk as a tea. Other people buy these substances in liquid form that they vaporize in electronic cigarettes. best cannabis edibles

What effects do synthetic cannabinoids have on the brain?

This product act on the same receptors in brain cells as THC ( delta-9-tetrahydrocannabinol ), the psychoactive ingredient in marijuana.

So far there have been few scientific studies on the effects of synthetic cannabinoids on the human brain, but researchers know that some of them adhere more strongly than marijuana to the receptors of THC-affected cells and may produce effects. much more powerful. The health consequences of this can be unpredictable and dangerous.

Since the chemical composition of many synthetic cannabinoid products is unknown and may vary from batch to batch, these products may contain substances that cause effects radically different from those the user might expect.

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Those who consume synthetic cannabinoids report some effects similar to those produced by marijuana:

High spirits
Relaxation
Altered perception: the person is not aware of the objects and the conditions that surround them
Psychosis symptoms: delirium or disordered thoughts disconnected from reality

The psychotic effects include:

Extreme anxiety
Confusion
Paranoia: extreme and unwarranted mistrust of others
Hallucinations: sensations and images that seem real but are not

What other adverse health effects can synthetic cannabinoids have?

People who consumed synthetic cannabinoid and entered the emergency room had severe symptoms, including:

Incrise of cardiac frecuency
Vomiting
Violent behavior
Suicidal thoughts

This prouduct can also raise blood pressure and reduce blood flow to the heart, damage the kidneys, and cause seizures. The consumption of these drugs is associated with an increasing number of deaths.

Are synthetic cannabinoids addictive?

Yes, synthetic cannabinoids can be addictive. Those who consume them regularly and try to quit may experience the following withdrawal symptoms:

Headaches
Anxiety
Depression
Irritability

Behavioral therapies and medications have not been specifically tested to treat addiction to these products. Health care providers should evaluate patients to determine if they have concurrent mental health disorders.

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Points to remember

The term “synthetic cannabinoids” refers to an increasing number of man-made chemicals that alter the mind.
These substances are sprayed on the dried and crushed matter of a plant or vaporized. Its consumption causes a high or “high”.
They are sometimes wrongly called “synthetic marijuana” or “false weed” because they act on the same receptors in brain cells as THC, the psychotropic ingredient in marijuana.
The effects of synthetic cannabinoids can be unpredictable and severe and can be life-threatening.
The only part of synthetic cannabinoid that is natural is dry plant matter. Chemical tests have shown that the active ingredients are man-made cannabinoid compounds.
Those who consume synthetic cannabinoids report some effects similar to those produced by marijuana:
High spirits
Relaxation
Altered perception
Psychosis symptoms
Synthetic cannabinoids can also cause serious physical and mental health problems, including:
Incrise of cardiac frecuency
Vomiting
Violent behavior
Suicidal thoughts
This can be addictive.
Behavioral therapies and medications have not been specifically tested to treat addiction to these products.

Cannabinoids and inflammatory skin diseases

The skin is the largest organ in the human body. Among the main functions of the skin is protected against external agents and it is the first defensive barrier of the innate immune system. Other important skin functions include regulating body temperature, maintaining hydroelectrolyte balance, and perceiving painful or pleasant stimuli. Any alteration in the functioning or appearance of the skin can have important consequences for physical and mental health. Many of the problems that occur in the skin are limited to it, but in some cases, the skin reveals a disorder that affects the entire body.

Drug Development in Dermatology

Almost 37% of primary care patients have an acute or chronic skin disease and it is surprising that the development of new drugs for the treatment of these pathologies, in particular, the diseases most commonly treated by dermatologists and non-dermatologists, it is surprisingly low compared to other pathologies. An important reason why few pharmaceutical companies develop drugs for dermatological diseases is that the economic performance of these drugs (especially topical products) is relatively small compared to the markets for drugs for other diseases (eg cardiovascular diseases) (Eaglstein and Corcoran, 2011). Buy CBD flower online

Another limitation to the development of drugs based on natural products including Cannabis sativa preparations is the impossibility, in most cases, of making adequate protection of intellectual property, which is essential to invest in the development of new drugs for any application. It is therefore not surprising that a large majority of skin diseases, especially inflammatory diseases, are treated with over-the-counter parapharmacy products and whose efficacy is not proven in most cases.

Cannabinoids in Dermatology

Topical use of Cannabis Sativa LIt dates back to ancient China, where cannabis preparations were used externally to treat skin rashes, ulcers, wounds, and hair loss. Equally, there is also archaeological evidence indicating that topical cannabis preparations were used by the Egyptians for eye conditions and also in wound dressings. Cannabis leaves were also used in medieval Arabic medicine to treat skin conditions such as pityriasis and lichen planus. In more modern times and at the beginning of the 20th century, before the prohibition period, cannabis tinctures were frequently sold in any pharmacy for the treatment of calluses, irritable bladder, menstrual pain and to stop opium addiction. among other applications. Buy marijuana online

The skin has all the elements of the endocannabinoid system, that is, endocannabinoid compounds (AEA and 2-AG), the metabotropic (CB1R and CB2R) and ionotropic receptors (TRPV-1) of cannabinoids and the enzymes involved in the synthesis and metabolism of endocannabinoids (eg FAAH and MAGL). The different elements of the endocannabinoid system are involved in key mechanisms of cutaneous regulation, such as control of epidermal growth and dermal annexes, cell survival, immune and inflammatory responses, the transmission of sensory stimuli to the Central Nervous System (pain, itching ) and lipid synthesis, among other activities.

Despite this long history of topical use of cannabis and advances in knowledge of the endocannabinoid system of the skin, research into the use of cannabinoids for skin pathologies is one of the youngest fields of research in this area and The clinical data on the use of cannabis in dermatological practice are extremely limited. However, there is increasing evidence of the potential of cannabinoids for the treatment of inflammatory skin diseases including psoriasis and atopic dermatitis, and for the treatment of autoimmune diseases such as scleroderma, which occurs with inflammation and fibrosis. Buy real marijuana online

Psoriasis

Psoriasis is one of the most common chronic inflammatory skin diseases characterized by hyperproliferation and desquamation of keratinocytes, by infiltration of T cells and neutrophils, and by activation of dendritic cells and macrophages. Although the pathogenesis of psoriasis is not fully understood, there is strong evidence that dysregulation of immune cells in the skin, particularly Th1 and Th17 cells, plays a critical role in the development of psoriasis.

Although there are currently only anecdotal results of the use of Cannabis sativa L preparations for topical use in psoriasis, the therapeutic possibilities of cannabinoids acting through CB2R and by mechanisms independent of classic cannabinoid receptors, are very broad due to their role in the regulation of Th1 and Th17 lymphocytes (Derakhshan and Kazemi, 2016). In addition, some phytocannabinoids have been shown to inhibit keratinocyte proliferation through independent pathways of CB1R and CB2R (Wilkinson and Williamson, 2007).

Atopic dermatitis

Atopic dermatitis (DA) is the most frequent chronic inflammatory disease of the skin, where the interactions of genetic, environmental, and immunological factors lead to its onset and progression. The clinical features of AD include dry skin due to loss of the epidermal barrier, erythema, oozing and crusting, and lichenification. Furthermore, AD presents with intense itching that leads to frequent scratching and staph infections. There is no cure for AD and the main goals of its treatment are to reduce symptoms (itching and dermatitis), prevent exacerbations, and minimize the risks of skin infections. Standard treatment modalities for the management of these patients focus on the use of topical anti-inflammatory corticosteroid preparations and skin hydration. Buy organic smart cart

Currently, there are numerous para pharmaceutical preparations based on Cannabis sativa L seed oil, especially hemp, for the treatment of AD. And despite the misleading advertising that often accompanies the marketing of this type of product, hemp seed oil does not contain cannabinoids or other bioactive phenolic compounds, so its therapeutic effect does not go beyond any other preparation that Contains polyunsaturated fatty acids that promote hydration of the skin.

However, based on preclinical studies, cannabinoids also have great potential for therapeutic management of AD (Ong PY, 2009; Wollenberg et al, 2014). In this sense, selective CB1R agonists inhibit mast cell activation and histamine release. Furthermore, the topical application of anandamide analogs attenuates skin inflammation in an animal model of DA (Kim et al, 2015). Other authors have suggested that the expression of CB1R in keratinocytes plays a relevant role in maintaining the epidermal barrier (Gaffal et al, 2014). Finally, selective CB2R agonists have also been reported to inhibit IgE-mediated inflammatory skin reaction and spontaneous pruritus in DA (Maekawa et al, 2006). Buy CBD cigarettes – regular

The antibacterial activity of Cannabis sativa preparations and phytocannabinoids has been a known fact for decades, although only more recently the antibacterial activity of cannabinoids THC, CBD, CBG and their precursors (acid forms) against staphylococci resistant to methicillin (Appendino et al, 2008).

About 100 cannabinoids and a good number of other bioactive compounds such as phenolics and terpenes have been identified in the plant, which also has important antioxidant and anti-inflammatory activities (Hanuš et al, 2016; Russo, 2011). Cannabinoids and the other types of compounds are thought to have synergistic effects between them, which would explain why some in vitro studies have obtained better results with plant extracts than with pure isolated compounds. Although the content of cannabinoids and other types of compounds is different depending on the variety of plants studied, it can be affirmed that cannabinoids have enormous potential for the treatment of AD due to their anti-inflammatory and antibacterial activities. Buy CBD cigarettes – menthol online

Cannabinoids and fibrotic skin diseases

Scleroderma or Systemic Sclerosis (SSc) is a rare autoimmune disease that involves three main features: fibroblast dysfunction leading to increased deposition of extracellular matrix proteins, small vessel vasculopathy resulting in tissue hypoxia, and immune response with production of proinflammatory cytokines and autoantibodies. SSc is characterized by progressive thickening and cutaneous fibrosis secondary to excessive accumulation of collagen, which can be limited to the skin (limited cutaneous SSc) or extend to internal organs (diffuse cutaneous SSc). SSc begins with microvascular injury and inflammation followed by fibroblast activation, a key event in the development of fibrosis.

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