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Cannabis Packaging is growing at an unprecedented rate, reaching $6.7 billion in sales in 2016. It is expected to grow to $50 billion by 2026. While it may still seem like this industry is relatively new (at least legally). The level of sophistication in the design and marketing of cannabis brands is rapidly accelerating. According to Ted Corless’s News Munchies blog, “Cannabis connoisseurs now care about the way marijuana has been managed. The density of the bud and the path it looks in a jar. Plus, cannabis packaging is everything. Some of the sought-after varieties come to us directly from celebrities, which perfectly combine brand and business.”
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With competition on the rise and regulation constantly changing from state to state, there is much for “mom-entrepreneurs” to consider when developing their products’ packaging, retail display, and marketing. Your product quality alone is not enough – you need to engage and educate the consumer within the retail environment to increase your market share and make significant sales. With this in mind, we’ve put together ten must-have pieces of information and guidance gathered from the Packaging Cannabis at The balcachem. They work directly with the cannabis industry daily.
1. The brand is KEY
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2. Let your product say for itself
Many budtenders may not have tested the product you are marketing and, as a result, may not sell very well. By improving your packaging with content that can be monitored via smartphone and linked to your business website, additional product information, customer reviews and more, potential buyers can learn more about your product in the retail environment. At the same time, holding it in hand or viewing your screen behind the counter. Linked content delivered at the right time can be the extra education needed to convert a potential customer into an enthusiastic fan.
3. Don’t forget to educate dispensaries too!
Many producers are using sample kits to market their products in dispensaries. A custom corrugated box that showcases your product and brand well makes a great first impression and can spark company interest in your merchandise. Digital printing provides an excellent solution for short-run case orders like these, where full-color graphics make a significant impact.
4. Maximize shelf company in limited space
Safety and security are top preferences for cannabis retailers. By law, all dispensaries must lock up cannabis products, which means production cases are the norm in this environment. Due to the space limits this makes, brands need to maximize their presence with a highly graphic and compact retail display, making the most of their limited space behind glass.
5. Know the rules where you grow
It seems obvious, but it is critical to make sure you are up to date with the state’s laws to grow and distribute your product. They have their own set of directions and regulations, and they are all different somehow. Remember: no cannabis can travel outside the state in which it is grown!
6. Respond with agility to security and regulatory labeling
From state to form and year to year, safety and regulatory labeling requirements for cannabis products constantly change. Because of this, their packaging and labels often need to be updated to comply with new or revised laws. Traditional printing methods such as flexo and litho-lam can have high entry costs due to the required purchase of printing plates and relatively high minimum volume orders. And all of this investment can quickly go to waste when a new law goes into effect, and you’re left with unused packaging inventory on your hands. With the development of affordable, high-quality digital printing for both labels and corrugated packaging, brands can now order the exact quantities needed to package their supply until the following significant change arrives and then quickly adapt to it.
Change without buying new plates – they can update their digital graphics file and place their next order! Since most cannabis brands sell several different strains and have uniquely labeled packaging for each, the savings with digital printing can be significant considering just the number of printed versions. Find more information about digital printing here.
7. Experiment
Cannabis brands are uniquely positioned to harness the industry’s rapid growth and consumer enthusiasm to push their brand to new heights. Discover better ways to connect with their audience through packaging. Digital printing offers so many options to get creative with your shelf presentation. You can easily change your artwork without a significant reinvestment of initial costs. Quick iterations to find what resonates with your audience are more accessible than ever to accomplish. And there’s plenty to play with, too: From product customization to variable graphic design, leading consumer brands show what’s possible in shelf impact (and ROI) with these techniques. Cannabis brands that do the same are sure to reap the benefits.
8. Buy in bulk where possible
Not all pieces of your packaging will have the potential to change as frequently as your labels. The order in bulk to lower your cost per item for primary packaging items like bags, pouches, bottles, and jars. Larger quantities = more considerable savings! If you’re currently ordering in volumes based on what you’ll need for your next shipment or two, consider partnering with a packaging provider that offers just-in-time inventory and warehousing services. This way, you can secure cost savings from a large order but only stock what you’ll need right away.
9. Save Labor and Time With a Label Applicator
Adding a label applicator to your community line speeds up your product packaging process. You can fulfill your orders quickly and improve your bottom line if you’ve been in the company with a constant dispensary retail base for a few years. You should consider this time-saving option!
10. Consider your Cannabis Packaging production timeline – Don’t wait until the last minute!
Because packaging plays such a significant role in the retail success of your product, hopefully, you’re planning your production schedule from the start. You can’t afford it. Traditionally printed packages (flexo, litho-lam) can take more than a month to produce. Fortunately, digital printing can deliver projects as short as 10-14 business days (5-10 for repeat orders). Talk to your packaging partner about your schedule and put it on your plan. Don’t give your Cannabis Packaging the short end of the stick and think about it at the last minute—it pays to plan.
In summary
Well, there you have it! 10 incredible facts about packaging for cannabis businesses, straight from the experts themselves. Remember, the only constant changes. For cannabis businesses willing to combine planning and creativity, the sky is the limit for how high their businesses can fly.
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A ѕtіmulаnt is a drug which ѕрееdѕ uр thе сеntrаl nеrvоuѕ system tо іnсrеаѕе nеurаl асtіvіtу іn thе brаіn. Exаmрlеѕ іnсludе аmрhеtаmіnеѕ, сосаіnе and сrасk, саffеіnе, nісоtіnе аnd есѕtаѕу. Stіmulаnt drugѕ tеnd tо mаkе реорlе fееl more аlеrt аnd focused аnd are ѕоmеtіmеѕ called ‘uрреrѕ’.
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During thе 1960ѕ, аѕ thеіr роtеntіаl fоr аbuѕе аnd аddісtіоn bесаmе арраrеnt, authorities bеgаn tо соntrоl ѕtіmulаntѕ like аmрhеtаmіnеѕ аnd thеіr mеdісаl use wаѕ rеѕtrісtеd. Nоw, ѕtіmulаntѕ аrе оnlу uѕеd fоr a ѕmаll numbеr оf mеdісаl соndіtіоnѕ ѕuсh as ADHD, narcolepsy, аnd оссаѕіоnаllу dерrеѕѕіоn. Thе mіld stimulant саffеіnе, hоwеvеr, rеmаіnѕ оnе оf оur mоѕt рорulаr drugѕ; bеіng fоund in tea, соffее and сhосоlаtе.
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Lаw еnfоrсеmеnt арреаrѕ tо bе сrасkіng dоwn оn methamphetamine in rесеnt уеаrѕ duе tо іtѕ rіѕе іn рорulаrіtу. According tо thе Drug Enfоrсеmеnt Admіnіѕtrаtіоn (DEA), mеthаmрhеtаmіnе ѕеіzurеѕ more thаn dоublеd frоm 2010 tо 2012.
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Although there are many ways to get CBD into your body, many people prefer gummies because of how they taste. CBD oils have been described as having an earthy, grassy, or nutty flavor. If this doesn’t sound appealing, you always have the option of finding oils with added flavor, mixing the CBD oil in your favorite drink, or doing what so many others do: eat some gummies.
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Another reason why so many people look for and consume CBD gummies is that they are convenient. It’s possible to carry this product around with you all day. It doesn’t matter if you’re headed to work, spending time with friends and family, or going out, you can bring your container of gummies with you and eat them when needed.
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When ingesting CBD in any form, it has to go through your digestive system, which means it may take a bit longer for you to feel the effects. When you eat gummies, the same process occurs, but that doesn’t mean that gummies are any less potent.
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Remember, sedatives are controlled substances and can be highly addictive. One should be careful in using these drugs as they may cause individuals to become dependent on them beyond their control. Use them in amounts prescribed by a doctor.
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Sedatives can induce both short- and long-term side effects – if not used cautiously.
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Taking sedatives in high dosage or mixing with other substances can lead to:
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Using sedatives for longer periods can induce mental health conditions, such as:
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depression,
fatigue,
frequent thoughts of physical harm to yourself or suicide,
The use of a heavy dosage of sedatives for longer periods can lead to dependency. In such a condition, your brain is reliant on this drug and you find yourself consuming it regularly. As a result, you may try to go beyond the prescribed dosage and start taking in large amounts and can’t stop taking them.
Dependency is also evident if you are having the same effect from a higher dose. It shows your body has become used to the drug and wants more to achieve the desired effect.
Withdrawal Symptoms
Dependency on sedatives is even more profound if you are experiencing withdrawal symptoms when you stop taking the drug. Withdrawal symptoms vary significantly from person to person depending on their history of drug use and accompanied by uncomfortable and painful physical and mental symptoms.
Some conspicuous withdrawal symptoms of Sedatives include:
irritability
increased anxiety
inability to sleep
seizures
you may become sick
Sleeping issues
That is why never stop taking sedatives at once. The best way is to gradually reduce the dosage and get rid of it in a couple of weeks or so.
Safety Precautions
Taking the Sedatives even in small quantities can lead to negative health conditions. You have to be extra careful while consuming prescription sedatives.
Start with a low dose and try to maintain it.
Avoid consuming Sedatives for more than a month as it may cause withdrawal symptoms.
Never mix this drug with other medicines having the same depressant effects. Doing so may lead to drowsiness and other harmful side effects.
Avoid mixing sedatives with alcohol or smoking marijuana while consuming sedatives may lead to severe and life-threatening symptoms like loss of consciousness or stopping breathing.
Children and pregnant women should not use sedatives without the guidance of a doctor.
Final Remarks
To conclude, taking the sedatives in the right amounts can help in treating anxiety and insomnia. You should be aware of its harmful side effects and follow the prescriptions of a doctor to avoid any potential sickness or withdrawal symptoms.
Synthetic cannabinoids are artificial (man-made) chemical compounds that alter the mind. They are sprayed on the dried and crushed matter of a plant so that they can be smoked, or sold as liquids that are vaporized and inhaled in electronic cigarettes or other devices. These products are also called herbal or liquid incense.
They are called cannabinoidsbecause they are similar to the chemicals found in the marijuana plant. Because of this similarity, synthetic cannabinoids are sometimes mistakenly called “synthetic marijuana” or “fake weed”. They are often marketed as legal and safe alternatives to that drug, but the reality is that synthetic cannabinoids pose risks and can affect the brain far more powerfully than marijuana. Its real effects can be unpredictable and, in some cases, more dangerous. These substances can become life-threatening. Buy cannabis indica online
Synthetic cannabinoids are a part of a gaggle of medication referred to as new hallucinogenic substances (NPS). These are substances that alter the mind but are not regulated. They have recently appeared on the market and their purpose is to cause the same effects as illegal drugs. Some of these substances may have been around for several years, but are now back on the market with different chemical structures or because they have regained popularity.
Manufacturers sell these products in colorful aluminum foil containers and plastic bottles to appeal to consumers. They market them under a wide variety of brands; There are currently hundreds of them, including K2, Spice, Joker, Black Mamba, Kush, and Kronic. Buy Hemp Seed Oil
For several years, it was easy to buy synthetic cannabinoid blends at novelty and drug paraphernalia stores, at gas stations, and online. Since the chemicals used in them do not have any medical benefits but have a high potential for abuse, the authorities have made the sale, purchase, and possession of these substances illegal. However, manufacturers try to circumvent the laws by modifying the chemical formulas of the mixtures.
The ease with which they can be obtained and the belief that synthetic cannabinoids is “natural” and therefore not harmful have probably contributed to consumption among young people. Another reason they are used on an ongoing basis is that traditional drug use tests do not easily detect many of the chemicals used in these products.
How are synthetic cannabinoids consumed?
The most common way to consume synthetic cannabinoids is to smoke the dry matter of the plant. That dry matter sprayed with synthetic cannabinoids is also sometimes mixed with marijuana or drunk as a tea. Other people buy these substances in liquid form that they vaporize in electronic cigarettes. best cannabis edibles
What effects do synthetic cannabinoids have on the brain?
This product act on the same receptors in brain cells as THC ( delta-9-tetrahydrocannabinol ), the psychoactive ingredient in marijuana.
So far there have been few scientific studies on the effects of synthetic cannabinoids on the human brain, but researchers know that some of them adhere more strongly than marijuana to the receptors of THC-affected cells and may produce effects. much more powerful. The health consequences of this can be unpredictable and dangerous.
Since the chemical composition of many synthetic cannabinoid products is unknown and may vary from batch to batch, these products may contain substances that cause effects radically different from those the user might expect.
Those who consume synthetic cannabinoids report some effects similar to those produced by marijuana:
High spirits
Relaxation
Altered perception: the person is not aware of the objects and the conditions that surround them
Psychosis symptoms: delirium or disordered thoughts disconnected from reality
The psychotic effects include:
Extreme anxiety
Confusion
Paranoia: extreme and unwarranted mistrust of others
Hallucinations: sensations and images that seem real but are not
What other adverse health effects can synthetic cannabinoids have?
People who consumed synthetic cannabinoid and entered the emergency room had severe symptoms, including:
Incrise of cardiac frecuency Vomiting Violent behavior Suicidal thoughts
This prouductcan also raise blood pressure and reduce blood flow to the heart, damage the kidneys, and cause seizures. The consumption of these drugs is associated with an increasing number of deaths.
Are synthetic cannabinoids addictive?
Yes, synthetic cannabinoids can be addictive. Those who consume them regularly and try to quit may experience the following withdrawal symptoms:
Headaches Anxiety Depression Irritability
Behavioral therapies and medications have not been specifically tested to treat addiction to these products. Health care providers should evaluate patients to determine if they have concurrent mental health disorders.
The term “synthetic cannabinoids” refers to an increasing number of man-made chemicals that alter the mind.
These substances are sprayed on the dried and crushed matter of a plant or vaporized. Its consumption causes a high or “high”.
They are sometimes wrongly called “synthetic marijuana” or “false weed” because they act on the same receptors in brain cells as THC, the psychotropic ingredient in marijuana.
The effects of synthetic cannabinoids can be unpredictable and severe and can be life-threatening.
The only part of synthetic cannabinoid that is natural is dry plant matter. Chemical tests have shown that the active ingredients are man-made cannabinoid compounds.
Those who consume synthetic cannabinoids report some effects similar to those produced by marijuana: High spirits Relaxation Altered perception Psychosis symptoms
Synthetic cannabinoids can also cause serious physical and mental health problems, including: Incrise of cardiac frecuency Vomiting Violent behavior Suicidal thoughts
This can be addictive.
Behavioral therapies and medications have not been specifically tested to treat addiction to these products.
Canine behavior can be inscrutable at times. Why do some dogs fall apart at the mere mention of going to the “v-e-t” while others walk through the door without a care in the world? And what about the nail decorations? Does your dog take them easily or show his best impression of Cujo? When faced with an anxious, aggressive, or just hyperactive dog, pet parents often crave a sedative (of course, for their dogs). But is this the correct answer?
Sedatives can play a role in helping dogs relax, but drugs are often misused. Let’s look at the common types of sedatives administered to dogs, how they work, and which ones are best in various circumstances.
Dealing with the underlying problem: anxiety in dogs
Anxiety, that feeling of nervousness, restlessness, or apprehension with which we are all familiar, is at the core of most behavioral problems in dogs. Sometimes anxiety is perfectly normal, but it becomes a problem when it is severe or frequent enough to have an adverse effect on the quality of life of the dog or the owner. If your dog is anxious, you may notice some combination of the following symptoms:
Tense muscles
Tremor
Panting
Attempts to escape from the situation, which can lead to destructive behavior.
Urination, defecation, release of the anal glands
Crouch or crouch close to the ground or try to hide in a “safe” place
Eyes wide open, sometimes with whites showing
Ears back
What to do about anxiety in dogs
Behavior modification is the best way to treat anxiety in dogs. These protocols generally involve teaching dogs to stay calm when exposed to mild versions of their triggers, rewarding them, and gradually increasing the intensity of their exposure as long as they remain calm.
However, sometimes it can be difficult for dogs to stay calm with even the mildest triggers. This is when medications and other anxiety relief products become invaluable. There are many over-the-counter options for mild anxiety, including:
Nutritional supplements like L-theanine, melatonin or S-adenosyl-methionine
synthetic pheromone preparations (for example, dog-appeasing pheromones or DAP)
body wraps that provide calming pressure
For moderate to severe anxiety, veterinarians turn to prescription anti-anxiety medications such as alprazolam, amitriptyline, buspirone, clomipramine, dexmedetomidine, diazepam, fluoxetine, lorazepam, paroxetine, sertraline, or trazodone.
Short-term sedative solutions for dogs
But what about cases where a dog’s behavior must be addressed before anxiety treatments can take effect or when they are inappropriate? What can be done for the hyperactive dog that needs to take it easy after surgery or the dog with a history of aggression that needs X-rays as soon as possible, for example? This is when a sedative might be a good idea.
Oral sedatives for dogs
Owners looking for a sedative to give their dogs at home have some limited options.
Acepromazine is the most commonly prescribed oral sedative for dogs. It is a member of the phenothiazine class of sedatives and works primarily by blocking dopamine receptors within the brain, which depresses certain brain functions. Unfortunately, acepromazine tablets can have highly variable effects on different individuals. Some dogs may not appear sedated at all, while others remain flat, even when given similar doses of the drug. Also, the onset and duration of the effect can be inconsistent and difficult to predict.
A potentially better option is to inject the liquid injectable form of acepromazine between the dog’s gums and cheek. The drug is absorbed through the oral mucous membranes and provides more reliable sedation. Regardless of how oral acepromazine is given, side effects such as low blood pressure and seizures may occur in people at risk.
Sometimes a vet will recommend a medicine that is traditionally used for other purposes for its sedating “side effects.” For example, the phenobarbital and gabapentin anticonvulsant medications are known to have a profound sedative effect when first administered to dogs, so they may also be prescribed for use prior to a potentially stressful event.
Treatment with more than one medication at a time will often improve a dog’s response to sedation. Possible combinations of oral sedatives include:
diazepam and butorphanol (an opioid pain reliever)
phenobarbital and diazepam
dexmedetomidine (an analgesic and pain reliever), ketamine (an anesthetic and pain reliever), and butorphanol. This combination can absorb through the oral mucous membranes.
Injectable sedatives for dogs
Whenever possible, it is preferable to administer sedatives by injection before oral administration because a dog’s response tends to be faster and more predictable. Most of the oral medications mentioned above are also available for use by injection. Popular injectable sedatives and injectable sedative combinations for dogs include:
acepromazine
acepromazine and butorphanol
diazepam and butorphanol
Telazol
Telazol and butorphanol
dexmedetomidine (can be reversed with atipamezole)
dexmedetomidine, ketamine, and butorphanol (can be partially reversed with atipamezole)
Your dog’s vet can determine which sedative is best for your dog based on the problem that needs to be addressed and your dog’s overall health. Regardless of the medication prescribed, be sure to closely follow the dosage instructions provided, never give more sedative than recommended, and speak to your vet about any questions or concerns you may have.
The skin is the largest organ in the human body. Among the main functions of the skin is protected against external agents and it is the first defensive barrier of the innate immune system. Other important skin functions include regulating body temperature, maintaining hydroelectrolyte balance, and perceiving painful or pleasant stimuli. Any alteration in the functioning or appearance of the skin can have important consequences for physical and mental health. Many of the problems that occur in the skin are limited to it, but in some cases, the skin reveals a disorder that affects the entire body.
Drug Development in Dermatology
Almost 37% of primary care patients have an acute or chronic skin disease and it is surprising that the development of new drugs for the treatment of these pathologies, in particular, the diseases most commonly treated by dermatologists and non-dermatologists, it is surprisingly low compared to other pathologies. An important reason why few pharmaceutical companies develop drugs for dermatological diseases is that the economic performance of these drugs (especially topical products) is relatively small compared to the markets for drugs for other diseases (eg cardiovascular diseases) (Eaglstein and Corcoran, 2011). Buy CBD flower online
Another limitation to the development of drugs based on natural products including Cannabis sativa preparations is the impossibility, in most cases, of making adequate protection of intellectual property, which is essential to invest in the development of new drugs for any application. It is therefore not surprising that a large majority of skin diseases, especially inflammatory diseases, are treated with over-the-counter parapharmacy products and whose efficacy is not proven in most cases.
Cannabinoids in Dermatology
Topical use of Cannabis Sativa LIt dates back to ancient China, where cannabis preparations were used externally to treat skin rashes, ulcers, wounds, and hair loss. Equally, there is also archaeological evidence indicating that topical cannabis preparations were used by the Egyptians for eye conditions and also in wound dressings. Cannabis leaves were also used in medieval Arabic medicine to treat skin conditions such as pityriasis and lichen planus. In more modern times and at the beginning of the 20th century, before the prohibition period, cannabis tinctures were frequently sold in any pharmacy for the treatment of calluses, irritable bladder, menstrual pain and to stop opium addiction. among other applications. Buy marijuana online
The skin has all the elements of the endocannabinoid system, that is, endocannabinoid compounds (AEA and 2-AG), the metabotropic (CB1R and CB2R) and ionotropic receptors (TRPV-1) of cannabinoids and the enzymes involved in the synthesis and metabolism of endocannabinoids (eg FAAH and MAGL). The different elements of the endocannabinoid system are involved in key mechanisms of cutaneous regulation, such as control of epidermal growth and dermal annexes, cell survival, immune and inflammatory responses, the transmission of sensory stimuli to the Central Nervous System (pain, itching ) and lipid synthesis, among other activities.
Despite this long history of topical use of cannabis and advances in knowledge of the endocannabinoid system of the skin, research into the use of cannabinoids for skin pathologies is one of the youngest fields of research in this area and The clinical data on the use of cannabis in dermatological practice are extremely limited. However, there is increasing evidence of the potential of cannabinoids for the treatment of inflammatory skin diseases including psoriasis and atopic dermatitis, and for the treatment of autoimmune diseases such as scleroderma, which occurs with inflammation and fibrosis. Buy real marijuana online
Psoriasis
Psoriasis is one of the most common chronic inflammatory skin diseases characterized by hyperproliferation and desquamation of keratinocytes, by infiltration of T cells and neutrophils, and by activation of dendritic cells and macrophages. Although the pathogenesis of psoriasis is not fully understood, there is strong evidence that dysregulation of immune cells in the skin, particularly Th1 and Th17 cells, plays a critical role in the development of psoriasis.
Although there are currently only anecdotal results of the use of Cannabis sativa L preparations for topical use in psoriasis, the therapeutic possibilities of cannabinoids acting through CB2R and by mechanisms independent of classic cannabinoid receptors, are very broad due to their role in the regulation of Th1 and Th17 lymphocytes (Derakhshan and Kazemi, 2016). In addition, some phytocannabinoids have been shown to inhibit keratinocyte proliferation through independent pathways of CB1R and CB2R (Wilkinson and Williamson, 2007).
Atopic dermatitis
Atopic dermatitis (DA) is the most frequent chronic inflammatory disease of the skin, where the interactions of genetic, environmental, and immunological factors lead to its onset and progression. The clinical features of AD include dry skin due to loss of the epidermal barrier, erythema, oozing and crusting, and lichenification. Furthermore, AD presents with intense itching that leads to frequent scratching and staph infections. There is no cure for AD and the main goals of its treatment are to reduce symptoms (itching and dermatitis), prevent exacerbations, and minimize the risks of skin infections. Standard treatment modalities for the management of these patients focus on the use of topical anti-inflammatory corticosteroid preparations and skin hydration. Buy organic smart cart
Currently, there are numerous para pharmaceutical preparations based on Cannabis sativa L seed oil, especially hemp, for the treatment of AD. And despite the misleading advertising that often accompanies the marketing of this type of product, hemp seed oil does not contain cannabinoids or other bioactive phenolic compounds, so its therapeutic effect does not go beyond any other preparation that Contains polyunsaturated fatty acids that promote hydration of the skin.
However, based on preclinical studies, cannabinoids also have great potential for therapeutic management of AD (Ong PY, 2009; Wollenberg et al, 2014). In this sense, selective CB1R agonists inhibit mast cell activation and histamine release. Furthermore, the topical application of anandamide analogs attenuates skin inflammation in an animal model of DA (Kim et al, 2015). Other authors have suggested that the expression of CB1R in keratinocytes plays a relevant role in maintaining the epidermal barrier (Gaffal et al, 2014). Finally, selective CB2R agonists have also been reported to inhibit IgE-mediated inflammatory skin reaction and spontaneous pruritus in DA (Maekawa et al, 2006). Buy CBD cigarettes – regular
The antibacterial activity of Cannabis sativa preparations and phytocannabinoids has been a known fact for decades, although only more recently the antibacterial activity of cannabinoids THC, CBD, CBG and their precursors (acid forms) against staphylococci resistant to methicillin (Appendino et al, 2008).
About 100 cannabinoids and a good number of other bioactive compounds such as phenolics and terpenes have been identified in the plant, which also has important antioxidant and anti-inflammatory activities (Hanuš et al, 2016; Russo, 2011). Cannabinoids and the other types of compounds are thought to have synergistic effects between them, which would explain why some in vitro studies have obtained better results with plant extracts than with pure isolated compounds. Although the content of cannabinoids and other types of compounds is different depending on the variety of plants studied, it can be affirmed that cannabinoids have enormous potential for the treatment of AD due to their anti-inflammatory and antibacterial activities. Buy CBD cigarettes – menthol online
Cannabinoids and fibrotic skin diseases
Scleroderma or Systemic Sclerosis (SSc) is a rare autoimmune disease that involves three main features: fibroblast dysfunction leading to increased deposition of extracellular matrix proteins, small vessel vasculopathy resulting in tissue hypoxia, and immune response with production of proinflammatory cytokines and autoantibodies. SSc is characterized by progressive thickening and cutaneous fibrosis secondary to excessive accumulation of collagen, which can be limited to the skin (limited cutaneous SSc) or extend to internal organs (diffuse cutaneous SSc). SSc begins with microvascular injury and inflammation followed by fibroblast activation, a key event in the development of fibrosis.
